肿瘤科

Investigation of Low-dose Abdominal Radiation Therapy for the Treatment of 猫的 Small Cell Gastrointestinal Lymphoma.

标题: Investigation of Low-dose Abdominal Radiation Therapy for the Treatment of 猫的 Small Cell Gastrointestinal Lymphoma.
联系人: 请联系 博士。迈克尔deveau,DVM,MS, directly with any questions regarding this trial and how to refer patients for consideration. Email is the preferred route of contact to ensure the quickest turnaround.
mdeveau@cvm.tamu.edu | (979)845-2351
种类: 猫的
Inclusion Criteria and General Background Information:
  • 大于1岁
  • Are any breed, size, sex, and weigh at least 2 Kg (4.5 lbs)
  • Confirmed histopathologic diagnosis of small cell gastrointestinal lymphoma.
  • No other series co-morbidities or other neoplasia (advanced heart disease, advanced kidney disease, etc)
  • Have no evidence of spread of the tumor outside the intestines, liver, spleen or lymph nodes within the abdomen at enrollment
  • Be deemed a good anesthetic candidate for 2 anesthesia periods, 24 hours apart
  • Must be on chlorambucil chemotherapy for > 1 month < 6 months prior to radiation therapy
  • Must be deemed during staging to be in a complete or partial remission based on intestinal infiltration.

The study will include a pre-radiation workup (CBC, Chemistry, urinalysis, three-view thoracic radiographs, and abdominal ultrasound), one CT scan for radiation therapy planning (done prior to and under the same anesthesia as the administration of the first radiation dose) and two episodes of radiation under generalized anesthesia administered 24 hours apart. Follow up rechecks at Texas A&M Small Animal Teaching Hospital at 2 weeks, 1 month, and every 3 months after completion of radiation therapy until relapse of disease or discontinued by investigators.

排除标准: 店主承诺: 财政奖励:
nginx

Use of a novel agent, RTI, to extend the disease free interval in dogs with lymphoma.

标题: Use of a novel agent, RTI, to extend the disease free interval in dogs with lymphoma.
联系人: 石楠威尔逊-罗夫莱斯,DVM,dacvim(肿瘤学)
oncology@cvm.tamu.edu | (979)845-2351
种类:
Inclusion Criteria and General Background Information: Must be a canine patient newly diagnosed with lymphoma, weigh at least 10 lbs, and is in good general health (outside of lymphoma diagnosis). Must be Stage 4 or less, substage a.

Lymphoma is a common tumor of the dog. The type of lymphoma that dogs get is very aggressive and >90% of them will die of the disease within 2 years even with aggressive therapy. The goal of this project is to see if a drug, RTI, originally used to treat tuberculosis in humans, can be used to create enhanced sensitivity of tumor cells to standard chemotherapy, i.e. make chemotherapy work better for longer.

排除标准: Canine individuals will not be eligible if they have ever received any form of other chemotherapy, received investigational therapy or radiation therapy. Canine patient must not have been given steroids for more than 14 days before enrollment.
店主承诺: Some staging expenses will be paid for by the owner including blood work, diagnosis of lymphoma and x-rays of the chest. The staging test will be determined by the senior clinician. In addition, any costs associated with the treatment of complications or accidental injuries associated with this study will also be covered at the owner’s expense. This will require weekly visits to the Texas A&M 兽医教学医院(vmth) for the entirety of the CHOP treatment (19 weeks) as well as monthly follow-ups for at least 8 months after completing chemotherapy.
财政奖励: